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Etoposide

SKU: orb1225270

Description

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number33419-42-0
MW588.56
Purity>98% (HPLC)
FormulaC29H32O13
SMILESO=C1OC[C@]2([H])C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C)OC[C@@]4([H])O3)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]21[H]
TargetTopoisomerase
SolubilityDMSO: 100 mg/mL (169.9 mM)

Bioactivity

In Vitro
Cell Viability Assay Cell line: HCT116 FBXW+/+, FBXW-/- and p53-/- cells. Concentration: 0.025 μM, 0.05 μM, 0.075 μM, 0.1 μM, 0.2 μM, 0.4 μM, 0.6 μM, 0.8 μM, 1 μM Incubation time: 72 hours. Result: Inhibits HCT116 FBXW+/+p>, FBXW-/- and p53-/- cell growth as a concentration manner. Western blot analysis. Cell line: HCT116 FBXW7+/+ or FBXW7-/- cells. Concentration: 25 μM. Incubation time: 6 hours. Result: Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

EPE | NSC 141540 | VP-16-123

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Etoposide (orb1225270)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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50 mg
¥ 910.00
100 mg
¥ 1,170.00
500 mg
¥ 2,080.00