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Eupatolide

SKU: orb1682589

Description

Eupatolide, a sesquiterpene lactone isolated from Inula japonica flowers, exhibits anti-inflammatory activity. It is a useful research tool for investigating mechanisms of TRAIL resistance in breast cancer cells, with applications in both in vitro and in vivo oncology studies.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number6750-25-0
MW248.32
FormulaC15H20O3
SMILESC=C1[C@]2([C@](OC1=O)(/C=C(\C)/CC/C=C(\C)/C[C@H]2O)[H])[H]
TargetDNA/RNA Synthesis,Prostaglandin Receptor,Akt,COX,PDGFR,MAPK,TNF,ROS,NOS,NO Synthase,NF-κB,Autophagy,Nrf2

Bioactivity

In Vitro
Eupatolide exhibits potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines IC50 1.57 to 22.58 uM). Eupatolide sensitizes breast cancer cells to TRAIL throug the down-regulation of c-FLIP expression. In RAW264. Cells, Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression by inducing proteasomal degradation of TRAF6. Eupatolide suppresses PDGF-induced proliferation and migration of VSMC through HO-1 induction via ROS-Nrf2 pathway and may be a potential HO-1 inducer for preventing or treating vascular disease.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

AP-1, Akt, COX, DNA Synthesis, DNASynthesis, HO-1, MAPK, Eupatolide, NOS, NOSynthase, Nrf2, NO Synthase, NO, PDGFR, NFκB, NF-κB, NFkB, NF-kB, p65, PGE, Prostaglandin Receptor, ProstaglandinReceptor, TNF-α, RNA Synthesis, RNASynthesis, ROS
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Eupatolide (orb1682589)

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