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FM26

SKU: orb1709682

Description

FM26 is a potent, allosteric inverse agonist of RORγt (IC50 = 264 nM) featuring a distinct isoxazole chemotype. It effectively suppresses IL-17A mRNA in EL4 cells in vitro and serves as a valuable tool for investigating Th17 cell biology and autoimmune disease pathways in research settings.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2407981-35-3
MW461.82
FormulaC22H15ClF3N3O3
SMILESC(NC1=CC=C(C(O)=O)C=C1)C=2C(=NOC2C=3C=CNC3)C4=C(C(F)(F)F)C=CC=C4Cl
TargetROR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

FM26 (orb1709682)

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