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FXR agonist 12

SKU: orb2944390

Description

FXR agonist12 (Compound C7) is an orally bioavailable small molecule that modulates bile acid homeostasis by repressing synthesis genes and inducing transport genes in HepG2 cells. It demonstrates efficacy in preclinical models, ameliorating ANIT-induced cholestasis and reducing liver injury and fibrosis in a mouse model of NASH.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1831862-88-4
MW404.626
FormulaC26H44O3
SMILESC[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(O)=O)C)(CC4)[H])[H])([C@H](O)[C@H](CC)[C@@]1(CCCC2)[H])[H])[H]
TargetFXR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

FXR agonist 12 (orb2944390)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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