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FXR agonist 3

SKU: orb1982428

Description

FXR agonist 3 is a potent small molecule that activates the Farnesoid X Receptor (FXR), demonstrating anti-NASH, antifibrotic, and hepatoprotective effects. It inhibits key fibrotic markers like COL1A1 (IC50 = 8.19 µM) in vitro and ameliorates liver injury in CDAHFD and BDL rodent models in vivo.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Metabolism Research

Images & Validation

Key Properties

MW521.12
Purity95.04% (May vary between batches)
FormulaC28H28BrNO4
SMILESCOC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]
TargetOthers,FXR
SolubilityDMSO:200 mg/mL (383.79 mM)

Bioactivity

In Vivo
In C57BL/6 N mice fed a CDAHFD diet for 16 weeks, FXR agonist 3 (200 mg/kg; oral gavage; daily for 4 weeks after CDAHFD-induced) decreased the expression of IL-1β and IL-6 in the liver.
In Vitro
In LX-2 cells, FXR agonist 3 (0, 2.5, 5, 7.5, and 10 μM; 24 hours; with or without 2 ng/mL TGF-β1 for another 24 hours) decreased COL1A1, TGF-β1, α-SMA, and TIMP1 protein expressions in a dose-dependent manner.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 640.00