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FXR agonist 5

SKU: orb1982262

Description

FXR agonist 5 is a synthetic small molecule activator of the Farnesoid X receptor (FXR). It is a valuable research tool for investigating liver diseases and metabolic inflammation, facilitating both in vitro mechanistic studies and in vivo preclinical models of cholestasis and NASH.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Metabolism Research

Images & Validation

Key Properties

CAS Number2414008-05-0
MW683.88
Purity99.74% (May vary between batches)
FormulaC40H53N5O5
SMILESCC=1C=C(C23CCC(CN(C(=O)[C@@H]4CC[C@@H](OC(=O)N5CC(O)C5)CC4)C6=CC(=CC=N6)C7=CN(C(C)(C)C)N=C7)(CC2)CC3)C=CC1OC
TargetFXR
SolubilityDMSO:100 mg/mL (146.22 mM)

Bioactivity

In Vivo
FXR agonist 5 (3 mg/kg or 6 mg/kg) increases serum FGF-19 levels, decreases serum C4 levels, and improves one or more clinical symptoms of BAM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information