Glucocorticoid receptor modulator 1

SKU: orb1745131

Description

Glucocorticoid receptor modulator 1 is a highly effective and orally administered NF-κB and AP-1 inhibitor with IC50 values of 9 nM and 130 nM, respectively. It can downregulate the expression of inflammatory factors IL-6, IL-1β, TNF-α, and MMP-13, thereby alleviating skin inflammation.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

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Key Properties

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CAS Number	2868357-11-1
MW	470.97
Purity	99.79%
Formula	C₂₄H₂₃ClN₂O₄S
SMILES	O=C(C=1C=CC=CC1)N2C3=CC=C(C=C3CCC2)NS(=O)(=O)C=4C=C(Cl)C(=CC4OC)C
Target	DNA/RNA Synthesis,TNF,Glucocorticoid Receptor,NF-κB,IL Receptor,MMP
Solubility	DMSO:80 mg/mL (169.86 mM)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

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Gene Symbol

DNA/RNA Synthesis,TNF,Glucocorticoid Receptor,NF-κB,IL Receptor,MMP

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