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GNF351

SKU: orb1308262

Description

GNF351 is a potent and selective aryl hydrocarbon receptor (AHR) antagonist, effectively inhibiting both DRE-dependent and -independent signaling with an IC50 of 62 nM. It exhibits low cytotoxicity in keratinocytes and is a valuable research tool for studying AHR biology in inflammatory, toxicological, and oncological contexts, both in vitro and in vivo.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1227634-69-6
MW411.5
Purity99.04%
FormulaC24H25N7
SMILESCC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
TargetAryl Hydrocarbon Receptor
SolubilityDMSO:124 mg/mL (301.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.72 mM)

Bioactivity

Target IC50
AhR:62 nM (IC50)
In Vitro
After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNF 351, GNF351, GNF-351, Inhibitor, inhibit, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, aryl hydrocarbon receptor, AhR

Similar Products

  • GNF351 [orb1219527]

    >98% (HPLC)

    1227634-69-6

    411.5

    C24H25N7

    1 g, 500 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
Quality Guarantee

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Key Properties

No computed properties available.

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GNF351 (orb1308262)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 1,950.00
10 mg
¥ 2,470.00
25 mg
¥ 4,420.00
50 mg
¥ 7,670.00
100 mg
¥ 10,140.00
200 mg
¥ 13,520.00
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