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GS-143

SKU: orb1217475

Description

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.

Images & Validation

Key Properties

CAS Number916232-21-8
MW466.46
Purity>98% (HPLC)
FormulaC28H19FN2O4
SMILESOC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
TargetIκBα phosphorylation
SolubilityDMSO:40 mg/mL (85.75 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: BALB/c mice (age 7-8weeks) injected with oval-bu-min. Dosage: 16 μg/body or 32 μg/body. Administration: Intranasal administration; once. Result: Suppressed antigen-induced NF-κB activation in the lung of sensitized mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GS 143 | GS143

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Protocol Information

GS-143 (orb1217475)

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Available Sizes

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2 mg
¥ 1,300.00
5 mg
¥ 1,950.00
10 mg
¥ 2,730.00
25 mg
¥ 5,200.00
50 mg
¥ 7,930.00
100 mg
¥ 11,700.00
500 mg
¥ 24,050.00