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GSK872

SKU: orb1690387

Description

GSK-872 is a potent and selective RIP3 kinase inhibitor, exhibiting high-affinity binding and inhibitory activity in the low nanomolar range. This compound is a valuable research tool for investigating necroptosis in both cellular and animal models, aiding the study of inflammatory and neurodegenerative diseases.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number1346546-69-7
MW383.5
Purity>98%
FormulaC19H17N3O2S2
SMILESCC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1
TargetKinase
SolubilitySoluble in DMSO (up to at least 25 mg/ml)

Bioactivity

Target IC50
RIP3K:1.8 nM
In Vivo
In compared with no treatment after ischemic injury in vivo, GSK872 can significantly reduce HIF-1α expression .
In Vitro
GSK872 (1 μM) has no inhibition for most of 300 human protein kinases tested. It fails to inhibit RIP1 kinase. In HT-29 cells, GSK872 concentration-dependently blocks TNF-induced necroptosis. In cell-based assays, there is a 100- to 1000-fold shift in the IC50 compared to the cell-free biochemical assays. GSK872 inhibits DAI- or TLR3-induced (RIP1-independent) death. It induces caspase activation and then induces apoptotic cell death.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK2399872A; GSK’872

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Key Properties

No computed properties available.

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GSK872 (orb1690387)

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5 mg
¥ 2,470.00
25 mg
¥ 4,940.00
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