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GSK2982772

SKU: orb1300025

Description

GSK2982772 is a potent and selective RIPK1 inhibitor, demonstrating IC50 values of 16 nM (human) and 20 nM (monkey). This small molecule is a valuable research tool for investigating RIPK1-mediated necroptosis and inflammation in both cellular and animal models of inflammatory and neurodegenerative diseases.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1622848-92-3
MW377.4
Purity>98%
FormulaC20H19N5O3
SMILESCN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O
TargetKinase
SolubilitySoluble in DMSO (up to 25 mg/ml)

Bioactivity

Target IC50
RIP1 (human):16 nM|RIP1 (monkey):20 nM
In Vitro
GSK2982772 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Receptor-interacting protein kinases, RIP kinase, RIP1, RIPK, RIPkinase, inhibit, Inhibitor, GSK2982772, GSK-2982772, GSK 2982772

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  • GSK-2982772 [orb1226039]

    >98% (HPLC)

    1622848-92-3

    377.404

    C20H19N5O3

    500 mg, 200 mg, 25 mg, 50 mg, 100 mg, 1 g, 5 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

GSK2982772 (orb1300025)

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5 mg
¥ 3,120.00
25 mg
¥ 7,020.00
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