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GSK3987

SKU: orb1305077

Description

GSK3987 is a synthetic ligand for Liver X Receptors (LXRα and LXRβ), demonstrating potent agonist activity by recruiting the steroid receptor coactivator-1 with EC₅₀ values of 40 nM. This small molecule is a valuable research tool for studying LXR-mediated pathways in lipid metabolism, inflammation, and atherosclerosis in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number264206-85-1
MW384.43
Purity99.92%
FormulaC24H20N2O3
SMILESCOc1ccc(NC2=C(C(=O)N(Cc3ccccc3)C2=O)c2ccccc2)cc1
TargetLiver X Receptor
SolubilityDMSO:50 mg/mL (130.06 mM)

Bioactivity

Target IC50
LXRα:40 nM(EC50)|LXRβ:40 nM(EC50)
In Vitro
In primary human macrophages, GSK3987 (30, 100, 300, 1000 nM) increased the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner. In human hepatoma (HepG2) cells, GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in a dose-dependent manner. GSK3987 showed activity with EC50s of 0.08 μM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LXR, LXRβ, LXRα, LiverXReceptor, Liver X receptor, Liver X Receptor, inhibit, macrophages, GSK3987, GSK-3987, GSK 3987, Inhibitor, HepG2 cells, ABCA1, cellular cholesterol, SREBP-1c, triglyceride accumulation
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

GSK3987 (orb1305077)

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Available Sizes

Select a size below

1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
10 mg
¥ 3,250.00
25 mg
¥ 5,200.00
50 mg
¥ 7,540.00
100 mg
¥ 10,140.00
DispatchUsually dispatched within 3-5 working days
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