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Handelin

SKU: orb1297537

Description

Handelin

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number62687-22-3
MW552.66
Purity99.35%
FormulaC32H40O8
SMILES[H][C@@]12CC[C@@](C)(O)[C@]34C[C@@]5(C(=O)O[C@@]6([H])[C@@]5([H])[C@H](C[C@@](C)(O)[C@]5([H])CC=C(C)[C@]65[H])OC(C)=O)[C@](C)(C=C3)[C@@]4([H])[C@]1([H])OC(=O)C2=C
TargetNF-κB,Immunology/Inflammation related
SolubilityDMSO:10 mg/mL (18.09 mM);10% DMSO+90% Corn Oil:1 mg/mL (1.81 mM)

Bioactivity

In Vitro
The present study was designed to investigat the anti-inflammatory potential of andelin in vitro and in vivo andelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264. Cells the suppression of NO and PGE2 production by andelin was correlated wit the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that andelin suppresse the induction of pro-inflammatory cytokines including TNF- ± and IL-1β as well as microRNA-155 in LPS-induced RAW264. Cells. Activation o the transcriptional activity of NF-κB by LPS was also alleviated by andelin, which was well coincided with its inhibitory effect on IκB degradation. In addition the activation of MAPKs such as ERK and JNK signaling was suppressed by andelin. In in vivo animal model, oral administration of andelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively the analysis of cytokine production in serum showed that andelin dose-dependently inhibite the production of IL-1β in a carrageenan-induced paw edema.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

NF-κB, NFkB, NF-kB, NFκB, NO Synthase, Nuclear factor-κB, Nuclear factor-kappaB, Inhibitor, inflammation, Inflammation related, Inflammationrelated, Immunologyrelated, Immunology related, inhibit, Handelin, PGE, TNF-α

Similar Products

  • Handelin [orb1217802]

    >98% (HPLC)

    62687-22-3

    552.7

    C32H40O8

    1 g, 500 mg, 200 mg, 100 mg, 5 mg, 25 mg, 50 mg, 10 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Handelin (orb1297537)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,430.00
5 mg
¥ 2,860.00
1 ml x 10 mM (in DMSO)
¥ 3,640.00
10 mg
¥ 4,420.00
25 mg
¥ 7,020.00
50 mg
¥ 9,880.00
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