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HBT1

SKU: orb1219460

Description

HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.

Images & Validation

Key Properties

CAS Number489408-02-8
MW386.39
Purity>98% (HPLC)
FormulaC16H17F3N4O2S
SMILESCc1cc(nn1CC(=O)Nc1sc2CCCCc2c1C(N)=O)C(F)(F)F
TargetGluR
SolubilityIn Vitro: DMSO : 250 mg/mL (647.01 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
5 mg
$ 80.00
10 mg
$ 120.00
25 mg
$ 220.00
50 mg
$ 320.00
100 mg
$ 530.00