Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

HBT1

SKU: orb1298638

Description

HBT1 is a glutamate-dependent AMPA receptor potentiator that enhances receptor activity and stimulates BDNF production with minimal intrinsic agonism in primary neurons. This molecule is used in vitro and in vivo to study synaptic plasticity, neuroprotection, and cognitive function in models of neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number489408-02-8
MW386.39
Purity99.48% (May vary between batches)
FormulaC16H17F3N4O2S
SMILESCc1cc(nn1CC(=O)Nc1sc2CCCCc2c1C(N)=O)C(F)(F)F
TargetGluR,iGluR
SolubilityDMSO:3.87 mg/mL (10.02 mM)

Bioactivity

In Vitro
HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BDNF, AMPA-R, AMPA, inhibit, Ionotropic glutamate receptors, Inhibitor, HBT 1, HBT1, HBT-1, iGluR, LBD, glutamate, primary neurons, S518

Similar Products

  • HBT1 Antibody [orb846497]

    ELISA,  WB

    Bacteria

    Rabbit

    Polyclonal

    Unconjugated

    2 mg
  • HBT1 [orb1219460]

    >98% (HPLC)

    489408-02-8

    386.39

    C16H17F3N4O2S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 90.00
50 mg
$ 120.00
100 mg
$ 160.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry