IL-15 mutant Recombinant Protein

SKU: orb1229914

Description

Research Area

Immunology & Inflammation

Images & Validation

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Application Notes	This recombinant proteins is for research use only.

Key Properties

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Source	CHO cells
Biological Activity	This mutant IL-15/Fc fusion protein specifically binds to the IL-15R, competitively inhibits IL-15-triggered cell proliferation, promotes transplant tolerance, does not activate the STAT-signaling pathway, and exerts a prolonged circulating half-life caused by the modified Fc domain.
Target	IL15
Tag	Fc Tag
Protein Sequence	The extracellular domain of human IL-15 (aa 49-162) including mutations at Q149D and Q156D is fused to the N-terminus of the Fc region of human IgG1.
Purity	>98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).

Storage & Handling

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Storage	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Form/Appearance	Lyophilized
Buffer/Preservatives	Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μl sterile water. Add 1X PBS to the desired protein concentration.
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Interleukin-15

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Quick Database Links

Gene Symbol

IL15

UniProt

Q9JKF4

RefSeq (Protein):NP_751914

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

Protein	NP_751914

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