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Indeglitazar

SKU: orb1308197

Description

Indeglitazar (PPM 204) is an orally bioavailable pan-PPAR agonist that simultaneously activates the α, δ, and γ subtypes. This small molecule is used in research to study metabolic diseases, with applications in both in vitro assays and in vivo models of dyslipidemia and insulin resistance.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number835619-41-5
MW389.42
Purity99.73%
FormulaC19H19NO6S
SMILESCOc1ccc(cc1)S(=O)(=O)n1cc(CCC(O)=O)c2cc(OC)ccc12
TargetPPAR
SolubilityDMSO:90 mg/mL (231.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.47 mM)

Bioactivity

In Vivo
In Zucker rat model of diabetes, Indeglitazar (10 mg/kg; i.v.) significantly lowers the levels of glucose, HbA1C, triglycerides. In the ob/ob model of diabetes and insulin resistance, Indeglitazar significantly decreases glucose, insulin, triglycerides, and free fatty acid levels. The level of Adiponectin (day 21) is essentially unchanged, thus the observed reductions in glucose and HbA1C are achieved in an adiponectin-independent fashion.
In Vitro
Measuring in part functional insulin sensitization capability of the cells, Indeglitazar shows an EC50 of 0.32 μM compared with Rosiglitazone, which shows an EC50 of 13 nM, in an assay of preadipocyte differentiation.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Indeglitazar, PPM 204, PPM204, PPM-204, PPARδ, PPARγ, PPARα
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Indeglitazar (orb1308197)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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2 mg
¥ 910.00
5 mg
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 2,210.00
50 mg
¥ 3,120.00
100 mg
¥ 4,420.00
200 mg
¥ 6,500.00
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