Indinavir sulfate

SKU: orb1220625

Description

Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	157810-81-6
MW	711.87
Purity	>98% (HPLC)
Formula	C₃₆H₄₉N₅O₈S
SMILES	OS(O)(=O)=O.CC(C)(C)NC(=O)C1CN(Cc2cccnc2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12
Target	HIV
Solubility	DMSO:100 mg/mL (140.48 mM)

Bioactivity

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In Vivo

Animal model: Nude mice(s. c. into Huh7 and SK-HEP-1 cells). Dosage: 70 mg/kg. Administration: Oral gavage; once a day for 3 weeks. Result: Delaied the growth of s. c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.

In Vitro

Cell Viability Assay Cell line: PBMCs (from healthy and HIV-infected volunteers). Concentration: 0-50 μM. Incubation time: 18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours). Result: Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner. Resulted in dose-dependent reduction of lymphoproliferative responses. Cell Invasion Assay Cell line: Huh7 and SK-HEP-1 cells. Concentration: 40 μM-40 nM. Incubation time: 5 days. Result: Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells. Western blot analysis. Cell line: Huh7 and SK-HEP-1 cells. Concentration: 40 μM-40 nM. Incubation time: 48 h. Result: Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MK-639 sulfate | L735524 sulfate

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Quick Database Links

Gene Symbol

HIV

Protocol Information

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