Indinavir sulfate

SKU: orb1301422

Description

Indinavir sulfate is a potent and selective HIV-1 protease inhibitor, exhibiting an IC50 of 0.41 nM and a Ki of 0.24 nM. It is widely used in biochemical assays and cell-based studies to investigate viral replication mechanisms and has been a key component in antiretroviral therapy research, both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	157810-81-6
MW	711.87
Purity	>99.99% (May vary between batches)
Formula	C₃₆H₄₉N₅O₈S
SMILES	OS(O)(=O)=O.CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
Target	SARS-CoV,HIV Protease,Apoptosis,MMP
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.62 mM);DMSO:125 mg/mL (175.59 mM)

Bioactivity

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Target IC50	HIV-1:0.41 nM
In Vitro	At low concentrations (0.0003-10 μmol/l) indinavir acts as a positive allosteric modulator (EC50 = 0.021 μmol/l), whereas at concentrations greater than 10 μmol/l (30-100 μmol/l) indinavir acts as an inhibitor of the α7-nicotinic acetylcholine receptor. Read more...

Storage & Handling

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Storage	store at low temperature,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Indinavir, Indinavir sulfate, Indinavir Sulfate, inhibit, Inhibitor, L 735524, L 735524 Sulfate, MK 639, MK 639 Sulfate, MK639, MK-639, MK639 Sulfate, MK-639 Sulfate, MK-639 sulfate, MMP, PBMC, hepatocarcinomas, Human immunodeficiency virus, Huh7, Matrix metalloproteinases, HIVProtease, HIV Protease, HIV, L735524, L-735524, L735524 sulfate, L735524 Sulfate, L-735524 Sulfate, CD4 T cells, Apoptosis, SARSCoV, SARS coronavirus, SARS-CoV

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Compound Identifiers

PubChem CID

5462355 ↗

Key Properties

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No computed properties available.

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