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INNO-220

SKU: orb3135415

Description

INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis). It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.

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Key Properties

CAS Number3032576-92-1
MW400.43
Purity98.95% (May vary between batches)
FormulaC23H20N4O3
SMILESO=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2)C=4C=NN(C4C=5C=CC=CC5)C)CC1
TargetCasein Kinase,MDM-2/p53,MALT,PROTACs,Molecular Glues

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

INNO-220 (orb3135415)

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5 mg
¥ 2,730.00
10 mg
¥ 4,160.00
25 mg
¥ 7,670.00
50 mg
¥ 11,960.00
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