ITGA4 (C) Antibody, Rabbit Polyclonal

Rabbit polyclonal to ITGA4.Integrin alpha-4 (ITGA4) is a single-pass type I membrane protein that belongs to the intergrin alphachain family. Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. Theyrecognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S inVCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T inMADCAM1. On activated endothelial cells, integrin VLA-4 triggers homotypic aggregation for mostVLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with targetcells.