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Jaceosidin

SKU: orb1225885

Description

Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties; promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells; shows selective suppression of proliferation (IC50 = 82.1 μM in HSC-3 cells and 97.5 μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.

Images & Validation

Key Properties

CAS Number18085-97-7
MW330.292
Purity>98% (HPLC)
FormulaC17H14O7
SMILESO=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13
TargetFlavonoids
SolubilityDMSO: Soluble ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

In Vivo
Animal model: 5-week-old male BALB/c mice (23-26 g). Dosage: 10 and 20 mg/kg. Administration: p.o. once a day for 3 days. Result: Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation. Animal model: Male Sprague-Dawley rats (180-200 g). Dosage: 20 mg/kg. Administration: p.o. , for 2 hour. Result: Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.
In Vitro
Cell Viability Assay Cell line: Hec1A, KLE, HES and HESC cells. Concentration: 3.125, 6.25, 12.5, 25, 50, and 100 μM Incubation time: 48 hour. Result: Showed cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

4'-Demethyleupatilin | Jaseocidin

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Jaceosidin (orb1225885)

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Available Sizes

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200 mg
500 mg
5 mg
¥ 2,470.00
10 mg
¥ 3,640.00
25 mg
¥ 7,020.00
50 mg
¥ 10,270.00
100 mg
¥ 14,430.00