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JAK1/2-IN-1

SKU: orb3133594

Description

JAK1/2-IN-1 is a potent inhibitor of JAK1 and JAK2, with IC50 values of 0.4 nM and 8.1 nM, respectively. Additionally, JAK1/2-IN-1 inhibits IL-4 and IL-13, with IC50 values of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a).

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Key Properties

CAS Number3023876-01-6
MW433.19
FormulaC19H19BF3N5O3
SMILESC(F)(F)(F)C1=C2C(=CC(NC=3N=C(N[C@@H]4[C@@H](C#N)CCOC4)C(C)=CN3)=C1)COB2O
TargetJAK,Interleukin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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JAK1/2-IN-1 (orb3133594)

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