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JHU395

SKU: orb1709368

Description

JHU395 is a stable, orally-bioavailable prodrug of the glutamine antagonist DON. It effectively delivers DON to malignant peripheral nerve sheath tumors (MPNSTs), demonstrating significant antitumor activity in both in vitro and in vivo models for cancer metabolism research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2079938-92-2
MW447.48
Purity99.75%
FormulaC22H29N3O7
SMILESC(OC(C(C)(C)C)=O)(OC(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)C1=CC=CC=C1
TargetOthers,Apoptosis
SolubilityDMSO:90 mg/mL (201.13 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.37 mM)

Bioactivity

In Vivo
JHU395 (oral gavage; 1.2 mg/kg × 5 days, 0.5 mg/kg × 9 days) delivers active GA to tumors with over twofold higher tumor-to-plasma exposure and significantly inhibits tumor growth in a murine flank MPNST model without observed toxicity.
In Vitro
JHU395 (1、10、100 μmol/L) inhibits the growth of multiple biosynthetic processes by tumor (MPNST) cells, while the growth of immortalized Schwann cells is minimally affected. JHU395 induces less PARP cleavage as a marker of apoptosis in human MPNST cells. JHU395 is a plasma-stable lipophilic GA prodrug that delivers DON to MPNST in an in vitro plasma-to-tumor cell partitioning assay measurement.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GA, JHU 395, JHU395, JHU-395, Apoptosis

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Key Properties

No computed properties available.

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JHU395 (orb1709368)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,430.00
5 mg
¥ 2,470.00
10 mg
¥ 3,900.00
25 mg
¥ 6,890.00
50 mg
¥ 10,530.00
100 mg
¥ 15,600.00
200 mg
¥ 20,800.00
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