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JT002

SKU: orb2278379

Description

JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2238820-43-2
MW432.49
FormulaC20H24N4O5S
SMILESN(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](OC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4
TargetNOD-like Receptor (NLR)

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

JT002 (orb2278379)

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