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JTE-607 HCl

SKU: orb1218557

Description

JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.

Images & Validation

Key Properties

CAS Number188791-09-5
MW525.3
Purity>98% (HPLC)
FormulaC22H29Cl4N3O3
SMILESO=C(N(CC)C1=CC=CC=C1)C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O.[H]Cl.[H]Cl
TargetCysteine Protease
SolubilityIn Vitro: DMSO : 250 mg/mL (418.51 mM)

Bioactivity

In Vivo
Animal model: Male C57BL/6 mice (5 to 6 weeks old) are sensitized by injecting Corynebacterium parvum. Dosage: 0.3, 1, 3, 10 mg/kg. Administration: Administered intravenously 10 min before the LPS challenge. Result: Showed dose dependent inhibition of the mortality at 0.3 to 10 mg/kg and significant effect at 3 and 10 mg/kg.
In Vitro
RT-PCR Cell line: human peripheral blood mononuclear cells (PBMCs). Concentration: 100 nM. Incubation time: 20 hours. Result: Reduced the increase in the level of mRNAs of TNF-α, IL-1b, IL-6 and IL-8.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JTE-607 | JTE 607 | JTE-607 HCl

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Protocol Information

JTE-607 HCl (orb1218557)

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% DMSO +
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% Tween 80 +
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Available Sizes

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200 mg
500 mg
2 mg
¥ 1,300.00
5 mg
¥ 1,950.00
10 mg
¥ 3,120.00
25 mg
¥ 6,110.00
50 mg
¥ 10,140.00
100 mg
¥ 14,300.00