KDM7 (C) Antibody, Rabbit Polyclonal

SKU: orb67003

Description

Rabbit polyclonal to KDM7.Lysine-specific histone demethylase 7 (KDM7) is a histone demethylase required for braindevelopment. KDM7 specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 andH3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue(H4K20Me1), thereby playing a central role in histone code. KDM7 specifically binds trimethylated'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3,it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2.

Research Area

Epigenetics

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution range	WB:1:500-1:1000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human KDM7
Molecular Weight	107
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-KDM7 antibody,anti-Lysinespecific demethylase 7 antibody,anti-JmjC domaincontaining histone demethylation protein 1D. JHDM1D antibody,anti- KIAA1718 antibody

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Western blot analysis of total cell extracts from human Hela using KDM7 antibody

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UniProt

Q6ZMT4

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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