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Keap1-Nrf2-IN-11

SKU: orb1744739

Description

Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α). By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2796292-75-4
MW765.9
FormulaC36H43N7O8S2
SMILESCCN1CCN(CC1)CCC(=O)NC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)N)C3=CC=C(C4=CC=CC=C43)N(CC(=O)N)S(=O)(=O)C5=CC=C(C=C5)OC
TargetROS Kinase,Others,NO Synthase,Nrf2

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

Keap1-Nrf2-IN-11 (orb1744739)

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