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KNK-437

SKU: orb1225645

Description

An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200 mg/kg).Colon Cancer Preclinical.

Images & Validation

Key Properties

CAS Number218924-25-5
MW245.2307
Purity>98% (HPLC)
FormulaC13H11NO4
SMILESO=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O
TargetHSP
SolubilityDMSO: ≥ 34 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KNK437

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    218924-25-5

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Protocol Information

KNK-437 (orb1225645)

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Available Sizes

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500 mg
5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 3,120.00
50 mg
¥ 5,330.00
100 mg
¥ 9,490.00
200 mg
¥ 13,000.00