L-Cysteinesulfinic acid

SKU: orb1992811

Description

L-Cysteinesulfinic acid is an endogenous neurotransmitter that acts as a broad agonist at multiple metabotropic glutamate receptors (mGluR1,2,4,5,6,8). It is used in neuroscience research to study excitatory amino acid signaling pathways and receptor pharmacology in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience

Images & Validation

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Key Properties

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CAS Number	1115-65-7
MW	153.16
Purity	99.96%
Formula	C₃H₇NO₄S
SMILES	[C@H](CS(=O)O)(C(O)=O)N
Target	Endogenous Metabolite,GluR
Solubility	H2O:110 mg/mL (718.2 mM)

Bioactivity

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Target IC50

In Vitro

CHO cells expressing mGluR1, mGluR5, and mGluR8 were treated with L-Cysteinesulfinic acid (L-CSA) for 45 minutes at 37°C, and receptor activation was assessed by measuring [³H]-inositol phosphate accumulation. The results showed that L-CSA activated mGluR1 and mGluR5, inducing IP formation with lower potency than L-glutamate but with significant activity. In cells expressing mGluR2, mGluR4, and mGluR6, L-CSA inhibited forskolin-induced cAMP production, indicating activation of these Gi/o-coupled receptors via inhibition of adenylyl cyclase .

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Human Endogenous Metabolite, LCysteinesulfinic acid, L-Cysteinesulfinic acid, L Cysteinesulfinic acid

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Compound Identifiers

PubChem CID

1549098 ↗

Key Properties

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No computed properties available.

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