Cart summary

You have no items in your shopping cart.

L48H37

SKU: orb1303256

Description

L48H37

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number343307-76-6
MW483.55
Purity99.26%
FormulaC27H33NO7
SMILESCCN1C\C(=C/c2cc(OC)c(OC)c(OC)c2)C(=O)\C(C1)=C\c1cc(OC)c(OC)c(OC)c1
TargetTLR,Others
SolubilityDMSO:45 mg/mL (93.06 mM)

Bioactivity

In Vivo
L48H37, administered via intraperitoneal injection at doses of 5 mg or 10 mg/kg once daily for 11 days, effectively inhibit the growth of H460 xenograft tumors and demonstrates significant anti-tumor effects in mice. This study utilized 5-week-old athymic BALB/cA nu/nu f Male mice weighing 18-22 g the treatment resulted in reduced tumor wet weights compared to the control group, decreased levels of phosphorylated STAT3, and increased levels of phosphorylated EIF2α and ATF4, indicating a potent anti-tumor response without causing significant structural alterations in the mice.
In Vitro
L48H37 effectively suppresses LPS-induced inflammation in mouse macrophages, particularly diminishing TNF-α and IL-6 production and gene expression. It also demonstrates noteworthy anticancer activity by reducin the viability of A549 and H460 lung cancer cells with IC50 Values of 5.3 μM and 2.3 μM, respectively outperforming curcumin. Importantly, its cytotoxicity towards normal human lung epithelial cells (BEAS-2B) remains low, with an IC50 of 21 μM. Moreover, L48H37 at concentration of 1, 2, or 4 μM over 16 hours decreases p-Cdc2 and Cdc2 levels, increases p53, enhances cleaved poly (ADP-ribosyl) polymerase (PARP) levels, and reduces anti-apoptotic protein Bcl-2 expression In both H460 and A549 cells, indicating apoptosis induction. Additionally, at 4 μM for 16 hours, L48H37 dose-dependently elevates intracellular ROS levels, as evidenced by increased DCF levels in these cells. Cell viability assays and Western Blot analysis confirm its concentration dependent efficacy in inhibiting lung cancer cell growth and modulating key proteins involved in cell cycle and apoptosis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Asthma, Curcumin, lung injury, LPS-TLR4/MD2, Inflammation, IL-6, inhibit, L48H37, L-48H37, Inhibitor, TLR4/MD2, Sepsis, TNF-α, Toll-like Receptor (TLR)
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

L48H37 (orb1303256)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,430.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
10 mg
¥ 1,820.00
25 mg
¥ 3,120.00
50 mg
¥ 4,680.00
100 mg
¥ 7,280.00
200 mg
¥ 10,010.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry