Latikafusp Antibody

SKU: orb1980395

Description

Latikafusp (AMG 256) is a bifunctional fusion protein that acts as a PD-1 antagonist and IL-21 receptor agonist, promoting antitumor immunity. It enhances cytotoxic and memory T-cell activity, applicable in immuno-oncology research for investigating immunogenicity in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2552814-07-8
MW	159.55 kDa
Purity	97.1% (SDS-PAGE); 97.4% (SEC-HPLC)
Target	PD-1/PD-L1

Bioactivity

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In Vivo

In cynomolgus monkeys, Latikafusp elicited strong immunogenic and hypersensitivity responses when administered intravenously at a dose of 5 mg/kg on days 1 and 15. Latikafusp was able to activate the classical and alternative complement pathways when administered intravenously at doses of 10 mg/kg and 30 mg/kg once a week for three weeks. In addition, cynomolgus monkeys in all dose groups exhibited strong antibody responses when Latikafusp was administered intravenously at 10 mg/kg and 30 mg/kg once a week over a three-week period, suggesting that the drug is highly immunogenic.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PD1, PD-1, PD1/PDL1, PD-1/PD-L1, AMG 256, AMG256, PDL1, PD-L1

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Gene Symbol

PD-1/PD-L1

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