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Licochalcone E

SKU: orb1684976

Description

Licochalcone E

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number864232-34-8
MW338.4
Purity98.09%
FormulaC21H22O4
SMILESCOc1cc(O)c(cc1\C=C\C(=O)c1ccc(O)cc1)[C@@H](C)C(C)=C
TargetTNF,Liver X Receptor,p38 MAPK,Autophagy,PPAR,Akt

Bioactivity

In Vitro
In this study the quantitative pharmacophores were constructed by 3D-QSAR pharmacophore (Hypogen) method based o the LXRβ agonists the optimal pharmacophore model containing one hydrogen bond acceptor, two hydrophobics and one ring aromatic was obtained based on five assessment indictors, includin the correlation between predicted value and Experimental value o the compounds in training set (correlation), α?cost o the models (α?cost), hit rate of active compounds (HRA), identification of effectiveness index (IEI) and comprehensive evaluation index (CAI). an the Values o the five assessment indicators were 0.95, 128.65, 84.44%, 2.58 and 2.18 respectively the best model as a query to scree the traditional Chinese medicine database (TCMD), a list of 309 compounds was obtained andwere then refined using Libdock program. Finally, based o the screening rules o the Libdock score of initial compound an the key interactions between initial compound and receptor, four compounds, demethoxycurcumin, isolicoflavonol, Licochalcone E and silydianin, were selected as potential LXRβ agonist

Storage & Handling

Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Liver X Receptor, LiverXReceptor, Licochalcone E, TNF-α, PPAR
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Key Properties

No computed properties available.

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Licochalcone E (orb1684976)

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1 mg
¥ 1,820.00
5 mg
¥ 5,070.00
10 mg
¥ 7,670.00
25 mg
¥ 11,960.00
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