Cart summary

You have no items in your shopping cart.

S14

SKU: orb1785944

Description

Lipidoid S14 is a novel lipidoid for siRNA delivery.Lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1β (siIL-1β) to macrophages and effectively suppress the pathogenesis of experimental arthritis induced by collagen antibody (CAIA mice). FS14-NP/siIL-1β achieved approximately 70% and 90% gene-silencing efficiency in the RAW 264.7 cell line and intraperitoneal macrophages, respectively. Intravenous administration of FS14-NP/siRNA led to rapid accumulation of siRNA in macrophages within the arthritic joints. Furthermore, FS14-NP/siIL-1β treatment lowered the expression of pro-inflammatory cytokines in arthritic joints and dramatically attenuated ankle swelling, bone erosion, and cartilage destruction.

Images & Validation

Key Properties

CAS Number2349307-29-3
MW994.73
FormulaC63H131N3O4
SMILESCCCCCCCCCCCCC(O)CN(CCCCNCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC

Storage & Handling

DisclaimerFor research use only

Similar Products

  • PSMD8 Antibody [orb865719]

    ELISA,  ICC,  IF,  IHC,  WB

    Human, Mouse, Rat

    Rabbit

    Polyclonal

    Unconjugated

    100 μg
  • RPS14 Rabbit Polyclonal Antibody [orb577534]

    WB

    Canine, Equine, Guinea pig, Mouse, Rabbit, Rat, Yeast, Zebrafish

    Human

    Rabbit

    Polyclonal

    Unconjugated

    100 μl
  • RPS14 Antibody [orb1676253]

    ELISA,  FC,  ICC,  IF,  IHC,  IP,  WB

    Human, Mouse, Rat

    Rabbit

    Polyclonal

    Unconjugated

    100 μg
  • Human Thyroid Hormone Responsive (THRSP) ELISA Kit [orb1948957]

    Human

    0.16-10ng/mL

    0.1 ng/mL

    96 T, 48 T
  • Human Thyroid Hormone Responsive (THRSP) ELISA Kit [orb777742]

    Human

    0.16-10 ng/mL

    0.058 ng/mL

    48 T, 96 T
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

S14 (orb1785944)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

25 mg
¥ 11,570.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry