Lisuride maleate

SKU: orb1685355

Description

Lisuride maleate is a non-selective dopamine agonist and G-protein-biased 5-HT2A receptor agonist that inhibits prolactin secretion. It is utilized in research models of Parkinson's disease, depression, and hyperprolactinemia for both in vitro receptor studies and in vivo behavioral and neuroendocrine experiments.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	19875-60-6
MW	454.52
Purity	99.85%
Formula	C₂₄H₃₀N₄O₅
SMILES	C(=C\C(O)=O)\C(O)=O.CN1[C@]2(C(C=3C=4C(C2)=CNC4C=CC3)=C[C@H](NC(N(CC)CC)=O)C1)[H]
Target	Dopamine Receptor,5-HT Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM);H2O:5 mM;Ethanol:5 mM;DMSO:20 mg/mL (44 mM)

Bioactivity

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In Vivo

Lisuride maleate, at doses of 0.78 mg/kg (intraperitoneal injection) and 3.13 mg/kg (oral administration), exhibits a potency that is 3-4 times higher when administered intraperitoneally compared to oral administration . When administered intraperitoneally (ip) at doses ranging from 0.78 to 3.13 mg/kg, Lisuride maleate effectively antagonizes the motor inhibition and hypothermia induced by reserpine . The effects of Lisuride maleate (0.78-3.13 mg/kg, intraperitoneal injection) are similar to those of apomorphine and D-amphetamine, and it can induce significant hypothermia at doses as low as 0.10 mg/kg .

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Lisuride Maleate

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Compound Identifiers

PubChem CID

5282421 ↗

Key Properties

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No computed properties available.

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