Cart summary

You have no items in your shopping cart.

Luminespib

SKU: orb1306830
FeaturedFeatured Product

Description

Luminespib

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number747412-49-3
MW465.54
Purity99.26%
FormulaC26H31N3O5
SMILESCCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O
TargetHSP,Autophagy,Apoptosis
SolubilityDMSO:16.67 mg/mL (35.81 mM);Ethanol:29 mg/mL (62.29 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:8.6 mg/mL (18.47 mM)

Bioactivity

Target IC50
HSP90 α:7.8 nM (cell free)|TRAP1:85 nM|HSP90 β:21 nM (cell free)|GRP94:535 nM
In Vivo
METHODS: To stud the effect on H. pylori-associated gastritis, Patchouli alcohol (5-20 mg/kg) was administered orally to H. pylori infected mice once daily for two weeks. Results: Patchouli alcohol treatment increased SH-NP content and CAT activity and significantly protecte the gastric mucosa from H. pylori-induced damage.
In Vitro
METHODS: H. pylori infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Apoptosis was detected by flow cytometry. Results: Patchouli alcohol treatment significantly reduced H. pylori-induced apoptosis. METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Cytokine levels were measured by ELISA. Results: Treatment with 5-20 µg mL Patchouli alcohol significantly reduce the production of TNF-α and MCP-1.
Cell Research
Cell lines were grown in DMEM/10% FCS, 2 mM l/L glutamine, and nonessential amino acids in a humidified atmosphere of 5% CO2 in air. All lines were free of Mycoplasma. Cell proliferation was determined usin the sulforhodamine B (SRB) assay for tumor cells and prostate epithelial cells the WST-1 assay for MCF10A and HB119, or an alkaline phosphatase assay for HUVEC and HDMEC. GI50 wa the compound concentration inhibiting cell proliferation by 50% compared with Vehicle controls. Cell cycle analysis was as described. Active caspase-3/7 was measured using a homogenous caspase assay kit.
Animal Research
in vivo pharmacokinetic studies in f Male NCr athymic mice bearing WM266.4 human melanoma xenografts were essentially as described. NVP-AUY922 was dissolved in DMSO and diluted in sterile saline/Tween 20. a single dose of 50 mg/kg NVP-AUY922 was given i.v. or i.p. and groups of three animals were taken at intervals for pharmacokinetic analyses.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

NVP-AUY 922, NVP-AUY922, NVP-AUY-922, Luminespib, inhibit, Inhibitor, Heat shock proteins, HSP, HSP90β, HSP90α, Autophagy, AUY 922, AUY922, AUY-922, Apoptosis, VER52296, VER-52296, VER 52296

Similar Products

  • Luminespib mesylate [orb1740720]

    747412-64-2

    479.57

    C27H33N3O5

    25 mg, 100 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Luminespib

Structure of Luminespib.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download
MSDS
Safety Data Sheet
Download

Request a Document

Protocol Information

Luminespib (orb1306830)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 2,210.00
25 mg
¥ 3,640.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry