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Lupeol acetate

SKU: orb1684440

Description

Lupeol acetate, a bioactive derivative of Lupeol, exhibits oral activity and diverse pharmacological properties including anti-cancer, anti-inflammatory, and anti-diabetic effects. It demonstrates cytotoxicity against Hep-3B and A549 cell lines in vitro and inhibits rheumatoid arthritis in vivo by downregulating key inflammatory mediators such as TNF-α, IL-1β, and COX-2.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience

Images & Validation

Key Properties

CAS Number1617-68-1
MW468.75
Purity99.84%
FormulaC32H52O2
SMILESC[C@]12[C@@]([C@@]3([C@@](C)(CC1)CC[C@H]3C(C)=C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](OC(C)=O)C5(C)C)[H])[H])[H]
TargetTNF,IL Receptor,COX,Interleukin,Others
SolubilityEthanol:1 mg/mL (2.13 mM)

Bioactivity

In Vivo
Methods: DBA/1J mice with collagen-induced arthritis (CIA) were andomly divided into three groups: Vehicle, Lupeol acetate-treated (5 mg/kg), and curcumin-treated (10 mg/kg) the therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduce the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improve the symptoms of RA by downregulatin the expression of inflammatory cytokines and osteoclastogenesis.
In Vitro
Methods: Lipopolysaccharide (LPS)-stimulated RAW 264. Cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-8 μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibite the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

TNF-α, 3-Acetyllupeol, Lupeol Acetate, Lupeyl acetate, NO Synthase, NOS
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Key Properties

No computed properties available.

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Lupeol acetate (orb1684440)

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Available Sizes

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1 mg
¥ 1,560.00
5 mg
¥ 2,860.00
1 ml x 10 mM (in DMSO)
¥ 3,120.00
10 mg
¥ 4,160.00
25 mg
¥ 6,630.00
50 mg
¥ 9,360.00
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