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LY2922470

SKU: orb1308099

Description

LY2922470 is a potent and selective GPR40 agonist, demonstrating EC50 values of 7 nM (human), 1 nM (mouse), and 3 nM (rat). It significantly lowers glucose while increasing insulin and GLP-1 secretion, making it a valuable research tool for studying metabolic diseases in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1423018-12-5
MW475.6
Purity97.08% (May vary between batches)
FormulaC28H29NO4S
SMILESCOc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12
TargetGPCR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.41 mM);DMSO:125 mg/mL (262.83 mM)

Bioactivity

Target IC50
FFA1/GPR40:1 nM(EC50,mouse)|FFA1/GPR40:3 nM(EC50,rat)|FFA1/GPR40:7 nM(EC50, human)

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FFAR, Free Fatty Acid Receptor, human GPR40, GPR40, Inhibitor, mouse GPR40, inhibit, LY 2922470, LY2922470, LY-2922470, rat GPR40
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

LY2922470 (orb1308099)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,950.00
5 mg
¥ 3,770.00
1 ml x 10 mM (in DMSO)
¥ 4,030.00
10 mg
¥ 5,460.00
25 mg
¥ 8,970.00
50 mg
¥ 12,610.00
100 mg
¥ 16,900.00
200 mg
¥ 22,490.00
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