Magainin 2

SKU: orb1296609

Description

Magainin 2

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	108433-95-0
MW	2466.9
Purity	100.00%
Formula	C₁₁₄H₁₈₀N₃₀O₂₉S
SMILES	CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(O)=O
Target	Antibiotic,Antifungal,Antibacterial
Solubility	DMSO:5 mM

Bioactivity

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In Vitro

Magainin 2 exhibits bactericidal activity by permeabilizing cell membranes and inducing early apoptosis-like morphological Changes in Escherichia coli. It enhance the expression of a bacterial protein with caspase substratee affinity and modulates RecA expression, akin to caspase-like proteins. Notably, it disrupts membranes without significant harm to mammalian cells, targeting primaril the lipid matrix. In Paramecium caudatum, a protozoan, magainin 2 at 10 μg mL induces osmotic swelling and cell burst by interfering with membrane functions crucial for osmotic regulation. Its mechanism differs in bacterial and mammalian cells; it forms approximately 2.8 nM pores in B. megaterium membranes and crosses int the cytosol, whereas in CHO-K1 cells, it causes significant membrane disturbance, allowing entry of molecules larger than 23 nM, and results in membrane budding and lipid redistribution, notably affecting mitochondria and nuclei.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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cell, cytotoxicity, Antibiotic, AMP, antimicrobial peptide, Bacterial, bacteria, inhibit, Inhibitor, Magainin II, Magainin2, Magainin-2, Magainin 2, gram-negative, gram-positive, Fungal, phospholipid, protozoa

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Compound Identifiers

PubChem CID

155486971 ↗

Key Properties

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No computed properties available.

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Magainin 2 (orb1296609)

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Purity:	> 95% by HPLC
MW:	2466.9 Da
Structure:	H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH

Purity:	> 95%
MW:	2466.95
Source:	Synthetic

Purity:	≥95%
MW:	2409.9

Purity:	≥95%
MW:	2466.95

CAS Number:	147664-63-9
MW:	2477.17
Formula:	C₁₂₂H₂₁₀N₃₂O₂₂

Magainin 2

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Magainin 2 (orb1296609)

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