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MB-07811

SKU: orb1308058

Description

MB-07811 (VK-2809) is an orally administered HepDirect prodrug of the active compound MB07344. It functions as a liver-selective thyroid hormone receptor beta (THR-β) agonist, demonstrated in research to effectively lower serum cholesterol and triglyceride levels in preclinical studies.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number852948-13-1
MW514.98
Purity99.94% (May vary between batches)
FormulaC28H32ClO5P
SMILESC(OC1=CC(C)=C(CC2=CC(C(C)C)=C(O)C=C2)C(C)=C1)P3(=O)O[C@@H](CCO3)C4=CC(Cl)=CC=C4
TargetThyroid hormone receptor(THR)
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.88 mM);DMSO:45 mg/mL (87.38 mM)

Bioactivity

In Vivo
In diet-induced obese mice, MB-07811 (0.3-30 mg/kg) decreases cholesterol and triglycerides.
In Vitro
MB-07811 has a low affinity for thyroid hormone receptors with a Ki of 14.6 μM for TRβ and a Ki of 12.5 μM for TRα.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MB07811, MB-07811, MB 07811, THR, THR-β, Thyroid hormone receptor, Thyroidhormonereceptor(THR), Thyroidhormonereceptor, Thyroid hormone receptor-β, Thyroid hormone receptor(THR), VK 2809, VK2809, VK-2809
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

MB-07811 (orb1308058)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,820.00
5 mg
¥ 4,030.00
10 mg
¥ 5,460.00
25 mg
¥ 8,320.00
50 mg
¥ 10,920.00
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