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MG-T-19

SKU: orb2802249

Description

MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number328540-44-9
MW596.6
Purity99.14%
FormulaC18H8Br2ClF3N4O2S
SMILESO=C(NC1=CC(Cl)=CC=C1O)C2=NN3C(N=C(C=C3C(F)(F)F)C=4SC=C(Br)C4)=C2Br
TargetImmunology/Inflammation related

Bioactivity

In Vivo
In a murine lung infection model, MG-T-19 (10 mg/kg, intranasal administration) significantly reduces bacterial burden in lung tissue, alleviates histopathological damage, and improves survival. MG-T-19 also enhance the efficacy of antibiotics like ceftazidime, showing synergistic antimicrobial effect.
In Vitro
MG-T-19 is a mannose-derived compound with antimicrobial activity. In vitro MG-T-19 (2-16 μg/ml) effectively inhibit the growth of various Pseudomonas aeruginosa strains, including drug-resistant clinical isolates. MG-T-19 blocks bacterial adhesion to host cells and prevents biofilm formation across different human cell model.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

MGT-19, MG T19
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

MG-T-19 (orb2802249)

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Available Sizes

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1 mg
¥ 3,120.00
5 mg
¥ 6,890.00
10 mg
¥ 9,620.00
25 mg
¥ 14,560.00
50 mg
¥ 19,890.00
100 mg
¥ 26,130.00
200 mg
¥ 35,490.00
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