Mianserin hydrochloride

SKU: orb1310297

Description

Mianserin hydrochloride is a tetracyclic antidepressant agent functioning as an antagonist at alpha-adrenergic, histamine H1, and specific serotonin receptors. It is utilized in neuropharmacology research to study receptor interactions and depressive disorder models, with noted sedative effects and potential hematological side effects in experimental settings.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	21535-47-7
MW	300.83
Purity	99.63%
Formula	C₁₈H₂₁ClN₂
SMILES	Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Target	Dopamine Receptor,Opioid Receptor,Histamine Receptor,Adrenergic Receptor,5-HT Receptor
Solubility	H2O:99.7 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.32 mM);DMSO:4.23 mg/mL (14.06 mM)

Bioactivity

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In Vivo

In elevated plus-maze experiments, Eltoprazine and Mianserin exhibit opposite effects: Eltoprazine induces anxiogenic-like behavior, while Mianserin triggers an anxiolytic-like response. Mianserin leads to a decreased number of these sites, whereas Eltoprazine results in an increase. Additionally, a subcutaneous dose of 2 mg/kg Mianserin produces a significant statistical increase in dopamine levels, exceeding 30% when compared to saline.

In Vitro

Mianserin dose-dependently elevates extracellular norepinephrine levels in the prefrontal cortex with minimal impact on the reuptake of norepinephrine in the rat cerebral cortex, due to its blockade of presynaptic inhibitory α2-adrenergic receptors and induction of regeneration-mediated release enhancement. In neonatal 6-OHDA-lesioned rats, mianserin attenuates the effects of SKF38393 and M-CPP, indicating that the actions of dopamine receptor agonists are mediated through the 5-HT neurochemical system. Additionally, in the medial prefrontal cortex of neonatal 6-OHDA-lesioned rats, 10 mg/kg S.C. Mianserin increased extracellular dopamine approximately 6-fold.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DA transporter, Dopamine Receptor, Dopamine, DopamineReceptor, 5HTReceptor, 5-HT, 5HT Receptor, AdrenergicReceptor, Adrenergic Receptor, HT, Histamine Receptor, HistamineReceptor, Org GB94, Org GB-94, ORG GB-94 HCl, OpioidReceptor, Opioid Receptor, Mianserin, Mianserin HCl, Sert (Sodium-dependent), κ-opioid receptor

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Compound Identifiers

PubChem CID

68551 ↗

Key Properties

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No computed properties available.

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