Minocycline hydrochloride

SKU: orb1309771

Description

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	13614-98-7
MW	493.94
Purity	99.28%
Formula	C₂₃H₂₈ClN₃O₇
SMILES	Cl.[C@@H]12[C@](C(=C3[C@H](C2)Cc2c(C3=O)c(ccc2N(C)C)O)O)(C(=O)C(=C([C@H]1N(C)C)O)C(=O)N)O
Target	MDM-2/p53,Antibiotic,Apoptosis,Calcium Channel,HIF/HIF Prolyl-Hydroxylase,Potassium Channel,Antibacterial
Solubility	H2O:12.4 mg/mL (25.1 mM);DMSO:257.5 mg/mL (521.32 mM)

Bioactivity

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Target IC50	NO production (LPS-induced BV2 cells):9.07 ± 0.86 μM\|NO production (LPS-induced RAW246.7 macrophages):34.81 μM\|Ih amplitude:41 μM\|MCF-7 cells viability:36.10 µM Read more...
In Vivo	Minocycline inhibits the release of cytochrome c mediated by the permeability transition in mitochondria. This inhibition by minocycline on cytochrome c release has been demonstrated in vivo, in cells, and isolated mitochondria. Additionally, minocycline suppresses the activity of inducible caspase-1 and caspase-3, inducible nitric oxide synthase (iNOS), and p38 mitogen-activated protein kinase (MAPK). Following experimental focal ischemia, minocycline reduces the upregulation of caspase-1 and iNOS, thereby decreasing infarct size. Read more...
In Vitro	Minocycline exhibits significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, Huntington's disease, and Parkinson's disease. Its neuroprotective properties may involve the inhibition of 5-lipoxygenase (an inflammatory enzyme associated with brain aging). Additionally, Minocycline's activity is linked to the inhibition of protein synthesis. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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cerebral ischemia, Apoptosis, Antibiotic, Bacterial, Ca channels, Ca2+ channels, Calcium Channel, acinetobacter, Hypoxia-inducible factors, HIFs, HIFProlylHydroxylase, HIF-PH, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF, MDM-2/p53, ovarian cancer, Minocycline, Minocycline HCl, Minocycline hydrochloride, Minocycline Hydrochloride, Mitochondrial ATP-sensitive potassium, neuroprotective, Inhibitor, L-type Ca2+ channel, Myocardial ischemia, infection, KcsA, inhibit, stroke, PI3K/Akt, Potassium Channel, Ventricular arrhythmia

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Compound Identifiers

PubChem CID

54685925 ↗

Key Properties

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No computed properties available.

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