Monensin

SKU: orb1309997

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Description

Monensin sodium salt, a polyether antibiotic derived from Streptomyces cinnamonensis, is a research tool for studying intracellular transport. It potently induces multivesicular body (MVB) enlargement and modulates exosome biogenesis and secretion, making it valuable for in vitro investigations of extracellular vesicle biology and cellular communication pathways.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	22373-78-0
MW	692.9
Purity	>90-95%
Formula	C₃₆H₆₁O₁ • Na
SMILES	[Na+].CC[C@]1(CC[C@@H](O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Target	Ionophore
Solubility	Soluble in DMSO (up to 25 mg/ml with warming)

Bioactivity

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In Vivo

LD50: Mice 335 mg/kg (i.g.) ; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.).

In Vitro

Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSC-343257

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Compound Identifiers

PubChem CID

23667299 ↗

Key Properties

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No computed properties available.

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Monensin (orb1309997)

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Applications:	ELISA, WB
Reactivity:	Other
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Bacteria
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

CAS Number:	22373-78-0
MW:	692.85
Formula:	C₃₆H₆₁NaO₁₁

Purity:	98.87%
CAS Number:	17090-79-8
MW:	670.87
Formula:	C₃₆H₆₂O₁₁

CAS Number:	30485-16-6
MW:	656.854
Formula:	C₃₅H₆₀O₁₁

Monensin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Monensin (orb1309997)

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