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MSA-2

SKU: orb1298624

Description

MSA-2

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number129425-81-6
MW294.32
Purity98.19%
FormulaC14H14O5S
SMILESCOc1cc2cc(sc2cc1OC)C(=O)CCC(O)=O
TargetSTING
SolubilityDMSO:255 mg/mL (866.4 mM);0.5% CMC-Na:12.5 mg/mL (42.47 mM)

Bioactivity

Target IC50
STING isoforms HAQ (human):24 μM|STING isoforms WT (human):8.3 μM
In Vivo
METHODS the EMT-6 mouse model was treated with MSA-2 (50 mg/kg, orally), an the Changes in intratumoral cytokines and chemokines after MSA-2 treatment in vivo were explored. Results IFN-β, IL-6, TNF-α, IFN-γ, and classical activation-associated chemokines including CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL9, and CXCL10 were significantly upregulated in EMT-6 tissues. METHODS: MSA-2 was orally administered at a single dose of 50 mg/kg to mice bearing U14 and TC-1 cervical tumor models. Mice were treated with 5 mg/kg of anti-PD-1 every Other day for a total of 3 treatments. Tumor volume was assessed every Other day. Result the tumor volume of mice was significantly reduced.
In Vitro
METHODS: PK-15 cells were treated with MSA-2 at concentration of 20, 30, 40 and 50 μM for 24 hours and then infected with SVV at 10 MOI. SVV RNA levels in treated cells were detected by RT-qPCR at 24 h post-infection (hpi). Results Viral RNA levels in MSA-2-treated cells were significantly reduced in a dose-dependent manner.
Animal Research
Animal Model was MC38 tumor-bearing C57BL6 mice an the dosage was 60 mg/kg.Administration was P.o.;s.c (50 mg/kg) Single dos

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

MSA 2, MSA2, MSA-2, MPYS, immunity, inhibit, Inhibitor, MITA, ERIS, interferon-β, MC38, secretion, TMEM173, TNF-α, Stimulator of Interferon Genes, STING, tumor

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Key Properties

No computed properties available.

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MSA-2 (orb1298624)

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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,040.00
2 mg
¥ 1,170.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
10 mg
¥ 2,210.00
25 mg
¥ 3,640.00
50 mg
¥ 5,720.00
100 mg
¥ 8,320.00
500 mg
¥ 17,160.00
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