Mutant IDH1 inhibitor

SKU: orb1308000

Description

This small molecule inhibitor potently targets the mutant IDH1 R132H enzyme with an IC50 under 72 nM. It is a valuable research tool for investigating oncogenic mechanisms in models of glioma and AML, supporting both in vitro and in vivo studies.

Research Area

Metabolism Research, Metabolism Research; Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1429180-08-4
MW	466.58
Purity	97.72% (May vary between batches)
Formula	C₂₅H₃₄N₆O₃
SMILES	CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(C)=O)cc2)n1
Target	Dehydrogenase,Isocitrate Dehydrogenase (IDH)
Solubility	DMSO:30 mg/mL (64.3 mM)

Bioactivity

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Target IC50	IDH1 (mutant, R132H):< 72 nM
In Vitro	Mutant IDH1 inhibitor is used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IsocitrateDehydrogenase, IsocitrateDehydrogenase(IDH), Isocitrate Dehydrogenase (IDH), Mutant IDH1 inhibitor, Mutant IDH-1 inhibitor, mutant IDH1 R132H, Isocitrate Dehydrogenase, inhibit, IDH, Inhibitor

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Compound Identifiers

PubChem CID

71542482 ↗

Key Properties

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No computed properties available.

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