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N-Arachidonylglycine

SKU: orb2901468

Description

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

Images & Validation

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N-Arachidonylglycine

Key Properties

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CAS Number179113-91-8
MW361.52
Purity>98% (HPLC)
FormulaC22H35NO3
SMILESCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O
TargetAntioxidant
SolubilityIn Vitro: DMSO : 100 mg/mL (276.61 mM; Ultrasonic (<60°C); )Ethanol : 50 mg/mL (138.30 mM; Ultrasonic)

Bioactivity

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In Vivo
N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold. N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells. Animal model: Rats. Dosage: 10 mg/kg. Administration: Oral. Result: Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid. Animal model: Mouse (peritonitis model). Dosage: 1.2 mg/kg. Administration: Oral; once. Result: Resulted in a significant 70% reduction of peritoneal cells.
In Vitro
N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells. N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm. Western blot analysis. Cell line: HEK293-GPR18 cells. Concentration: 0.1 nM-100 μM Incubation time: 5 min. Result: Drove MAPK activation.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • N-Arachidonoyl glycine [orb1704323]

    >98%

    179113-91-8

    361.53

    C22H35NO3

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Gene Symbol
Antioxidant

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