N-(p-Coumaroyl) serotonin

SKU: orb1297274

Description

N-(p-Coumaroyl) Serotonin, a safflower seed polyphenol, is a research compound studied for its antioxidant, cardioprotective, and anti-atherosclerotic properties. It is utilized in cardiovascular research, particularly in models investigating vascular distensibility and aortic wall function in vivo.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	68573-24-0
MW	322.36
Purity	98.89% (May vary between batches)
Formula	C₁₉H₁₈N₂O₃
SMILES	Oc1ccc(\C=C\C(=O)NCCc2c[nH]c3ccc(O)cc23)cc1
Target	PDGFR,Caspase,ERK
Solubility	DMSO:66.67 mg/mL (206.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.2 mM)

Bioactivity

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In Vitro

As reactive oxygen species (ROS) are implicated in the signaling of lipopolysaccharide (LPS), we examined whether CS has a suppressive effect on inflammatory cytokine generation from human monocytes in vitro. CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity. ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS. Northern blot analysis showed that LPS-induced expression of these cytokine mRNA in monocytes was suppressed by CS. NF-kappaB activation was also inhibited by CS

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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dysfunction, distensibility, atherosclerosis, aortic wall, anti-inflammatory, N (p Coumaroyl) serotonin, inhibit, N(pCoumaroyl) serotonin, N-(p-Coumaroyl) serotonin, NF-κB, PDGFR, Platelet-derived growth factor receptor, Inhibitor, VSMC, TNF-α, ROS

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Compound Identifiers

PubChem CID

5458879 ↗

Key Properties

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No computed properties available.

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