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Navitoclax

SKU: orb1223641

Description

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of 350 nM); disrupts Bcl-2/Bcl-xL interactions with pro-death proteins (e.g., Bim), induces apoptosis, shows cellular activity against a panel of human tumor cell lines (EC50<1 uM); induces complete tumor regressions in xenograft models of NSCLA and ALL.Blood Cancer Phase 2 Clinical.

Images & Validation

Key Properties

CAS Number923564-51-6
MW974.6127
Purity>98% (HPLC)
FormulaC47H55ClF3N5O6S3
SMILESO=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
TargetBcl-2
Solubility10 mM in DMSO

Bioactivity

In Vivo
Animal model: Mice with NCI-H1650 model. Dosage: 100 mg/kg. Administration: Orally; daily; for 21 consecutive days. Result: As a single agent, 100 mg/kg alone dosed daily had no significant antitumor activity. Notably, the combination with OSI-744 resulted in 98% TGI and durable tumor regressions in 100% of treated tumor-bearing mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ABT-263 | ABT 263 | ABT263

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Navitoclax (orb1223641)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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500 mg
5 mg
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 1,950.00
50 mg
¥ 2,860.00
100 mg
¥ 3,640.00
200 mg
¥ 5,200.00