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NDI-Lyso

SKU: orb2802036

Description

NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2999646-19-2
MW1469.69
FormulaC71H100N22O13
SMILESO=C1C=2C3=C4C(C(=O)N(CCCCCC)C(=O)C4=CC2)=CC=C3C(=O)N1CCC(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CC6=CC=CC=C6)=O
TargetApoptosis,Caspase

Storage & Handling

Storage-20°C
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Protocol Information

NDI-Lyso (orb2802036)

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